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Fluconazol 150 online, 3-year exposure and 5-year follow-up. Results: Adverse events included 24% of patients. No serious adverse events were reported. In conclusion, the results of 5-year follow-up adjunctive adufexol in the management of psoriasis are generally positive. PURPOSE: The objective of study was to evaluate the 5-year outcome of patients treated with adjunctive adufexol in the treatment of psoriasis. METHODS: A total of 796 patients who were randomized to receive adjunctive adufexol 150, 150 mg orally every other day, or oral placebo were enrolled in the study at 5 sites throughout France and completed the study in course of 12 weeks (2001 to 2004). During the 5-year follow-up period we recorded all clinical data, including efficacy and safety of adjunctive adufexol. PRINCIPAL FINDINGS: Overall, the majority of patients treated with adjunctive adufexol 150 achieved a significant reduction in Psoriasis Area and Severity Index (PASI) from baseline to end of observation without any significant increase in the number of flares (40%), and/or the number of new psoriatic lesions (15%). Adjunctive adufexol 150 had no harmful effects. CONCLUSION: The results of 5 years follow-up patients exposed to adjunctive adufexol 150 indicate that the treatment effect of adjunctive adufexol 150 is generally positive and may be associated with a good long-term outcome. © 2012 John Wiley & Sons A/S. It's not easy being a professional baseball player these days, but at least Chris Davis is playing with an up-and-coming young star in Manny Machado. "It's nice," Davis said Friday, "to be with a guy that has an incredible chance of having impact on the game at some point." That kind of praise from the Orioles' new center fielder is a welcome addition after he was benched a month ago and spent in Miami after making some poor comments about teammate Adam Jones as a young shortstop. While the Orioles don't want to risk anything too early, Davis said he feels more confident than last spring when he was dealing with his own issues and felt like he was being singled out by head coach Buck Showalter. "You feel bad when you're in your own head. You can really be on a roller coaster. You get little depressed and everything," Davis said. "But as long you don't let your head go down and don't try to take yourself out of the game, you should feel really confident." Machado has established himself as a legitimate three- or four-category threat — with his power, speed and defense.